If you didn’t already know, you can slow down the natural ageing process, and even reverse it! NMN supplements boost your natural NAD+ levels in the body. NAD+ is responsible for DNA repair, energy metabolism, cell signalling, and much more, so by raising these levels, you can feel young once again! This blog will discuss NMN benefits, the different NMN supplements you can take, and exactly how NAD+ provides you with so many different benefits.
What is NMN?
Nicotinamide mononucleotide (NMN) is a derivative of Vitamin B3. It is a molecule that is found naturally in the body and is a precursor to NAD+, a coenzyme that plays a critical role in metabolism and other cellular pathways and is found in all living cells. However, once a human is middle aged, these levels could have fallen to half of what they were. But, due to NMN directly increasing NAD+ levels in our bodies, taking NMN supplements counteracts the natural decline that occurs as we age by raising NAD+ levels. When you first take NMN it firstly synthesizes in the body then the molecules enter the nicotinamide core recycling pathway, where the enzyme nmnat then converts NMN to NAD+. This can result in NAD+ levels in older people being raised to the NAD+ levels of a 20-year-old! But what are the benefits of higher NAD+ levels?
What Are the Benefits of NMN?
There are many NMN benefits. NMN has several anti-ageing and health-promoting effects, and as mentioned can help offset age-associated weight gain. But why is this?
As mentioned, when you get older your NAD+ levels decline with age; this is associated with a variety of age-related diseases. NAD+ is required for the activity of enzymes called NA+- dependent enzymes. These are involved in a wide range of metabolic reactions, so by increasing NAD+ levels via NMN supplements, it can aid these metabolic reactions. Examples of the metabolic reactions it aids include:
NAD+ is a cofactor in the conversion of food into energy (ATP) via cellular respiration. More specifically, NAD+ is used in the electron transport chain, which is the final step of cellular respiration that results in the production of ATP. ATP is the primary source of energy for all living cells and is essential at aiding exercise training, specifically to support the three energy systems: ATP-PC, Fast Glycolytic, and Aerobic energy systems. By increasing the levels of NAD+ in the body, NMN benefits the process by helping to enhance the efficiency of the electron transport chain, and boost the production of ATP, resulting in an increased energy metabolism. Due to NMN research finding that the enhanced NAD+ levels led to oxygen uptake, percentages of maximum oxygen uptake, power at first ventilatory threshold, and power at second ventilatory threshold increased, this meant that NMN users had improved physical performance, increase endurance, and reduced fatigue.
NAD+ acts as a substrate for enzymes called poly ADP-ribose polymerases (PARPs), which are responsible for repairing DNA damage. When DNA is damaged, PARPs are activated, bind to the damage site, and use NAD+ to add ADP-ribose molecules to the target proteins. This process creates a signalling cascade that attracts other DNA repair proteins to the site of damage, such as DNA repair enzymes, helicases, and endonucleases. The repair proteins then remove, repair, or replace the damaged DNA.
NAD+ is also important for the activation of enzyme called sirtuin, which plays a key role in maintaining the stability of chromosomes and controlling the cell cycle. Sirtuins act as deacetylases and remove acetyl groups from target proteins, promoting their activity and stability. By removing acetyl groups from histones, sirtuins can also relax chromatin structure, allowing the repair proteins to access the damaged DNA Sirtuin SIRT6 deacetylates and activated histone H3K9, which regulates chromatin remodelling and influences the accessibility of DNA to the transcription machinery.
Therefore, NAD+ is critical for DNA repair since it enables the activation of PARPs and sirtuins, which are responsible for recruiting and activating other DNA repair proteins to fix the damaged DNA. Because NAD+ levels decline with age; by using NMN to increase NAD+ levels, these elevated NAD+ levels will enhance DNA repair. One study found that NMN supplementation in mice increased NAD+ levels, and improved DNA repair in the brain, this led to NMN benefits such as a decrease in age-associated cognitive decline. Other studies in mice have also shown that alongside repairing DNA, NMN also reduces the incidence of cancer.
We recommended taking our NMN alongside our SIRT6Activator for optimal NMN benefits. Our SIRT6Activator product enhances DNA double-strand break repair under oxidative stress. For the science behind this please visit DoNotAge.org science page.
NAD+ plays a critical role in cell signalling by acting as a substrate for sirtuins, which are NAD+ dependent enzymes. As mentioned, sirtuins are involved in a wide range of cellular processes. Including cell growth, differentiation, and ageing. They are also involved in the regulation of gene expression, energy metabolism, and stress response. Research shows that sirtuins are activated by NAD+. Previous research found that NMN supplementation led to NMN benefits in mice by increasing NAD+ levels and activating the sirtuin SIRT1, which led to improved insulin sensitivity and glucose tolerance. SIRT1 deacetylates and activates the transcription regulator FOXO3, this regulates cell size, cell survival (apoptosis), and stress resistance.
Overall NMN benefits us by its ability to increase NAD+ levels in the body which has been shown to be a promising approach for enhancing cell signalling and improving the function of sirtuins.
In summary, Sirtuins are important for cell signalling because they can regulate the activity of various proteins that are involved in cell signalling. By removing acetyl groups from target proteins, sirtuins can promote their activity and stability, and influence the expression of genes and the activity of enzymes that are involved in cell signalling.
When using NMN supplements the body converts this into NAD+, and boost levels of NAD+ in the body. This leads to the NMN benefit of improved metabolic reactions. In terms of ageing, NMN research suggests this molecule could be involved in other facets of ageing, such as heart and brain function. Previous research of NMNs usage after chemotherapy found that NMN increases survival chances and prevents deteriorating heart function following chemotherapy.
Previous research suggests that NMN administration improves vasodilation of blood vessels, thus increasing blood flow to the brain, helping to improve cognitive function. Some studies surrounding NMN’s effects have suggested that NMN and NAD levels may be reduced in patients with a variety of age-related ailments, such as diabetes and liver disorders. Therefore, by using NMN supplements, this can help to elevate these levels, and help to improve impaired glucose tolerances by restoring normal NAD+ levels and enhancing insulin sensitivity or insulin secretion.
Does NMN Help Alzheimer’s?
Animal testing utilising NMN supplements have also shown other NMN benefits like the capability to treat underlying causes of Alzheimer’s disease such as decreases in oxygen consumption rate and mitochondria abnormalities. It does this by boosting NAD+ levels, which helps to repair key brain cells as, Alzheimer’s is caused when these key cells in your brain are damaged.
What Is the Best NMN Supplement?
DoNotAge.org offer scientifically trusted NMN supplements in the form of NMN capsules and pure NMN powder this supplement has been scientifically proven to increase energy levels, and promote anti-ageing. This NMN supplement is the gold standard for purity so you enjoy optimum NMN benefits. It is also tested independently by third-party laboratories to confirm high purity and low heavy metal content. DoNotAge.org also guarantees the purity and quality of their NMN supplements.
How Long Does It Take to Feel the Benefits of NMN?
NMN converts into NAD+ within 15 minutes. However, you may not experience any noticeable NMN benefits immediately. People start to feel NMN benefits within different timescales. Some consumers have started to notice effects after the first two to three weeks, whilst it has taken others a couple of months. The supplement should be taken for six months for clear NMN Benefits to manifest.
What Is the Difference Between NMN Capsules and NMN Powder?
NMN Capsules are a convenient and easy way to take NMN supplements. They are pre-measured, and easy to swallow, this makes them a good option for people who have difficulty swallowing pills, or who prefer a more convenient way of taking supplements. Capsules also tend to have a longer shelf life than powders and are less likely to degrade over time to give you optimal NMN benefits.
NMN Powder, on the other hand, is a more versatile form of the supplement but provide the same NMN benefits. It can be mixed with water or other liquids to make a drink, NMN powder can also be easily adjusted to a specific dosage. However, if the supplement is not stored correctly, it might degrade over time.
How Much NMN Should I take?
If you are taking NMN capsules from DoNotAge.org, two capsules will give you 1000mg of NMN, which provides you with optimum NMN benefits as this amount equates to a healthy daily level of NAD+. With DoNotAge.org’s NMN Powder one scoop equates to 500mg, so 2 scoops daily is the recommended amount for optimum NMN benefits, that will give you the NAD+ needed to see the best results.
How Do You Get NMN Naturally?
NMN is naturally found in small amounts in fruits and vegetables:
However, 1 cucumber has 1.04mg to 6.4mg of NMN in it. This means to get the NMN benefits you get in DoNotAge.org’s NMN powder and NMN capsules, you would need to consume 156-961 cucumbers per day… that’s a lot of cucumbers!
What Are the Side Effects of Taking NMN Supplements?
We have tens of thousands of happy members who take our NMN powder and NMN capsules and previous research on the administration of NMN suggests that that taking NMN causes no significant deleterious effects. What is more, no side effects of taking NMN supplements have been found in humans.
Although research on humans is in its early stages, the results so far have been very promising. There have not been any serious side effects recorded from using NMN, only NMN benefits have been recorded and prior research has shown that using NMN triggers anti-inflammation immune systems able to reverse cytokine storm.
NMN Supplement Summary
Overall NMN benefits the body in many ways. It is a great supplement for boosting NAD+ levels which has a range of benefits from: increased energy metabolism, DNA repair, cell signalling, and more. Although more research is needed to fully understand the mechanisms by which NAD+ levels impact these processes, results thus for have been extremely positive.
We recommend using DoNotAge.org’s NMN alongside: Pure Resveratrol, SIRT6Activator, and Pure TMG for the best NMN benefits! What are you waiting for? Get NMN benefits by purchasing DoNotAge.org’s NMN and start your journey to living a healthier and longer life now!