It’s no secret that there are a range of NMN supplement benefits, such as improvements to cognitive function, anti-ageing, muscle recovery.
However, with all of the fake and ineffective NMN supplements out there you would be wise to want to see it to believe it. Therefore, this blog will discuss the different studies regarding the effects people experienced before & after NMN, as well as people’s own first-hand accounts.
In the NMN study conducted on humans, ten healthy male subjects were given NMN, and it was well-tolerated without causing any severe adverse events.
This was the first study that was conducted on humans. The study utilised a nonblinded clinical trial in 10 healthy men. Men that were deemed unfit e.g., had prior diseases, infections and, psychiatric disorders were excluded. The subjects orally received 100, 250, or 500mg of NMN in capsules at 9AM after overnight fasting. They were observed for 5 hours afterwards whilst being able to drink water freely. With urine collections being taken every 30-60 minutes for the first 2 hours and at the end of the 5 hours.
The administration of NMN did not affect heart rate, blood pressure, oxygen saturation, nor body temperature. However, the researchers found that some of the metabolites that are produced when NMN is broken down in the body (MNA, 2Py, and 4Py), despite already being present in the participants' blood at the start of the study, increased significantly at all doses tested when taking NMN supplements.
MNA (mono-nicotinamide) is a molecule that has been shown to have anti-inflammatory properties and may also have a role in regulating blood sugar levels.
2Py (2-pyridone) is a molecule that has been found to be involved in a variety of biological processes, including the production of energy in cells, the regulation of gene expression, and the protection of cells from damage.
4Py (4-pyridone) is another molecule that is involved in the production of energy in cells and may also play a role in protecting cells from damage.
This is significant as it suggests that higher doses of NMN may result in greater NAD+ production and potentially greater health benefits. The plasma concentration of MNA tended to moderately increase. After taking different doses of NMN, the levels of 2Py and 4Py, two chemicals in the body, were measured. The highest levels of these chemicals were seen 5 hours after taking the NMN.
The results of this study suggest that a single oral administration of NMN is safe for healthy humans and that it may lead to increased levels of certain NMN metabolites. These NMN metabolites have been associated with improved cognitive function, improved energy, muscle recovery, and mood. This also showed that NMN was well-tolerated and did not cause any adverse effects. Therefore, it showed that NMN consumption led to improvements in health.
Alzheimer's disease is a degenerative brain disorder that affects millions of people worldwide. It is the most common cause of dementia, a group of disorders that affect memory, thinking, and behaviour. As the population ages, the number of people with Alzheimer's disease is expected to increase significantly in the coming years. There is no cure for Alzheimer's disease, but there are ways to manage its symptoms and slow its progression.
One potential natural remedy for Alzheimer's disease is NMN it’s a molecule that is naturally produced in the body and is involved in cellular energy production. NMN has been shown to have anti-ageing properties and to improve cognitive function in animal studies.
Research has shown that Alzheimer's symptoms before compared to after taking NMN were a lot worse, showing that NMN supplements improved Alzheimer's disease symptoms in animal models. In a study published in the Journal of Alzheimer's Disease, mice with Alzheimer's disease were given NMN orally for 12 weeks. The study found that NMN treatment improved cognitive function and reduced the build-up of beta-amyloid plaques in the brain, which are characteristic of Alzheimer's disease. Therefore, taking NMN supplements may have potential as a treatment for Alzheimer's disease.
The author of the Reddit NMN before and after post had heard about NMN (nicotinamide mononucleotide) and resveratrol from a podcast. As someone who is interested in nootropics and other supplements for human optimisation, they decided to try the NMN + resveratrol stack. However, they were not taking it for longevity purposes, but rather for cognitive enhancement.
The author is a 27-year-old male who exercises 3-5 times a week with a combination of running and gym workouts. They work a cognitively demanding and stressful job and experience some low-level depression but do not take any prescribed antidepressants. Before trying NMN, they were already taking fish oil, vitamin D, CoQ10, and St. John's Wort. They typically sleep for 7.5-8 hours per night and limit their caffeine intake to one cup of coffee per day, with tea as a substitute on weekends. They also smoke one cigarette per day.
In the first month of taking NMN and resveratrol, the author felt an incredible rush of energy and mental clarity. They described feeling like they were on amphetamines and their mental exhaustion dissipated. They were able to go to the gym, study while after the gym, and do harder workouts than before. They needed constant mental stimulation and always had a podcast playing in their ears. They also started thinking about expanding their career in ways they wouldn't have considered before. However, they noted that they felt emotionally numb and became increasingly impatient. They were irritable with the slow pace of life and slept only 5-6 hours per night for the first week. After the first week, they crashed and slept for 14 hours.
In the second month, the author decreased the dose of NMN. They still felt the rush of energy but had trouble sleeping and became increasingly impulsive and irritable. They made mistakes at work that they normally wouldn't have. They took a few days off to catch up on sleep, during which they felt a little hazy, but attributed it to overworking. The reason for this is because they took their supplements before bed rather than in the morning.
In the third month, the author settled on a dose between the 2 doses tested prior. They found that their mental capacity for conversation and work had increased by 10-15% compared to when they weren't taking NMN. They could sleep better at this dose and didn't feel as sped up as before. They described it as feeling like a good cup of coffee. They also noticed that their optimal sleep time had decreased to 7-7.5 hours, which they attributed to the NMN either masking their sleep deprivation or improving their sleep quality.
The author reflected that, at their age, they were taking NMN more as a cognitive booster/nootropic than for its longevity benefits. They believe that their NAD+ (nicotinamide adenine dinucleotide) levels were optimal before taking NMN, but the effects of NMN were undeniable. The author found that the improvements in sleep quality alone made taking NMN worth it for them. They considered everything else to be a bonus.
After hearing about NMN (nicotinamide mononucleotide) on a podcast and reading about NMN, this person decided to try it out for themselves and review how they felt before and after taking NMN. They didn't find a specific forum for NMN, so they're posting their experience here since NMN and resveratrol are similar molecules. They're curious if anyone else has experienced similar positive effects.
They've been taking NMN powder mixed with water every morning after breakfast and coffee for three weeks. They're a 6'3", 195lbs, 38-year-old male in good health who takes no medications.
This was the first thing they noticed after two nights. They fell asleep quickly, had deep and dream-filled sleep, and woke up refreshed.
They used to experience knee pain when climbing stairs, but that pain disappeared after about a week of taking NMN.
They felt like they had more endurance during workouts and seemed to recover quickly with little muscle soreness afterwards.
They felt like they had more energy overall, but it's not a speedy, caffeinated feeling.
They used to get hangovers after drinking, but they haven't experienced any hangovers during this experiment.
They've noticed an immediate improvement in bowel movements.
They've been in a good mood despite dealing with major life stress and feel like they can recover from stress more easily.
Overall, they're surprised and delighted by the results and haven't noticed any negatives. They're cautiously optimistic that these improvements aren't just a placebo effect. They feel like they're getting some of their youthful energy and vitality back.
Are you looking for a supplement that can improve your cognitive function, muscle recovery, and even anti-ageing? Look no further than NMN. This supplement has been studied in humans and found to be safe and well-tolerated, with no adverse effects. Additionally, animal studies suggest that NMN may have the potential to improve Alzheimer's disease symptoms and cognitive function. With all these potential benefits, it's worth trying NMN for yourself. See the difference for yourself!
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