Nicotinamide Adenine Dinucleotide (commonly known as NAD) is essential to life. Without it we would die within seconds. It is a coenzyme that is found in all of your cells and is important for many processes, the mitochondria, ATP production (energy) and for a healthy metabolism.
Dinucleotide means that it consists of two nucleotides, one nucleotide contains adenine and one contains nicotinamide. If you’ve done any research on NAD recently, you may have seen it called numerous names such as NAD, NAD+ or even NADH. What is the reason for all of these names? NAD+ is given the plus sign to show the molecules positive charge and the specific chemical state. NADH is the specific opposite chemical state that NAD can be found in your cells. Essentially, this is the reduced form of NAD.
These are two forms that NAD exists in. It has the ability to switch between these two forms and that is what allows NAD to carry out its main function. The main function is to carry electrons from one reaction to another to produce energy and assist in the role of metabolism.
NAD and NADH help to convert nutrients from your food into energy that your cells can then use.
As we age, our NAD levels decrease. There are two main reasons why our NAD levels decline and they are as simple as…
- The production of NAD declines
- The consumption of NAD increases.
Your mitochondria are the powerhouse of every cell in your body and they use the energy to repair themselves when they’re damaged and they help to maintain homeostasis. If your mitochondria aren’t working effectively, this can have several effects in terms of your health and can lead to a number of age related brain problems.
NAD is also vital for the telomeres which are the caps on the end of your DNA strands that protect your chromosomes. Shorter telomeres are also linked to shorter lifespan. The loss of telomeres can lead to senescent cells or the death of cells.
NAD and Sirtuins
NAD is the fuel used by your Sirtuins and similar to NAD levels, sirtuin activity declines with age.
Sirtuins are a family of 7 proteins that keep your cells healthy and help to repair damaged DNA. They can only do their job when there is enough NAD to keep them fuelled.
Think of your body as a business. Sirtuins are the head of the business and NAD represents the wages of the employees and the space, training and equipment that is needed for the employees to fulfil their job role. The business (in this instance, your body) cannot function without the employees and as mentioned above, NAD declines with age meaning this impacts your sirtuins too. Sirtuins manage everything that happens in your cells and if these are failing to perform then ultimately the business will fail.
This is why we provide NMN and apigenin, to boost your NAD levels. Then to further activate your sirtuins, we provide resveratrol and our novel SIRT6Activator, which has been shown to extend lifespan.
CD38 is an enzyme that increases as we age, in conjunction to NAD decreasing. CD38 is an NADase which in simple terms means it reduces NAD levels. If you are boosting your NAD levels whilst your CD38 levels are too high, it will be less effective, therefore we provide apigenin and quercetin to inhibit CD38, in order to make your NAD boosting more effective.
Boosting NAD Levels
Over the years, NAD has become one of the leading topics of conversation in the longevity world and one of the most popular questions is how can we raise our NAD levels?
The NAD molecule is too large for your body to absorb, so we must look at alternative methods. Tthere are a number of different ways you can raise your levels. We provide Nicotinamide Mononucleotide (NMN) which is a direct precursor to NAD and has been proven to raise NAD levels. There are other ways of raising your NAD levels and these include exercise, intermittent fasting, getting enough sleep, eating healthily and protecting your body from too much direct sunlight.
Doing a combination of the above factors means that you are giving yourself the best shot at extending your health span and reaping the benefits of a much longer and healthier life.
We provide the world’s first NAD Test Kit that you can use from home, anywhere in the world. Our NAD Fixing Buffer provides the real magic, keeping the blood usable during shipping, ensuring accurate results.
“The loss of NAD as we age, and the resulting decline in sirtuin activity, is thought to be a primary reason our bodies develop diseases when we are old but not when we are young.” – David Sinclair, Lifespan Why We Age and Why We Don’t Have To