The word "senolytic" comes from senescence and -lytic. A senescent cell has lost its power of division and growth. A word ending with "lytic" just means to destroy. So, a senolytic is something that destroys senescent cells in the body. Senescent cells are detrimental and contribute to ageing. They increase as we get older and create a toxic micro-environment around them, leading to the creation of even more senescent cells.

There are several ways to reduce senescent cells. Fasting has been shown to be one of the most powerful methods, particularly extended fasts, typically lasting 4 or 5 days twice per year. It's essential to seek medical advice before undertaking extended fasts for correct supervision and to avoid negative outcomes. Ongoing intermittent fasting is also beneficial, and DoNotAge recommends intermittent fasting throughout the year for its numerous longevity benefits. Many people find it easiest to have a four-hour eating window each day, commonly referred to as 20:4.

Exercise is another effective way to reduce senescent cells. Studies have proven its positive effects. A 2016 study shows that exercise prevents both the accumulation of senescent cells and the expression of cells associated with causing senescence and inflammation.

In the latest studies, certain supplements have demonstrated a senolytic effect greater than the methods mentioned above. The most powerful senolytic supplement is fisetin, a plant flavonoid found naturally in certain foods. The highest concentration of fisetin in food is found in strawberries. Unfortunately, to get enough fisetin to activate its senolytic qualities, one would need to eat hundreds and hundreds of strawberries every day. As is often the case with products, the best ingredients for your body have been found and concentrated into easy-to-consume capsules. Nature provides the answers, and these supplements help enhance their benefits!