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  • Made to GMP & ISO9001 standards
  • Third-party tested, batch by batch

DoNotAge® Routine

15 ingredients. One daily DoNotAge® Routine.

Make space for a simple daily habit, with clear ingredient information, research you can explore and a team you can talk to.

$203.00Every 4 weeksCompared to buying the ingredients separately: $683.00
$7.25per day

You pay $203.00 every 4 weeks, under our subscription terms.

1 free pouch

Subscribe to DoNotAge® Routine between November 1 and November 30 and receive a free DoNotAge® Performance pouch with your first order, delivered together.

Everything included

Included free

$174.00 value
  • Open DoNotAge® storage box with eight daily sachets. The lid reads: Mix one sachet in your shaker with water. Take it at the same time as a meal. See you tomorrow.Box For Life$59.00Free
  • DoNotAge® shaker pouring a raspberry drink into a glassExclusive shaker$20.00Free
  • DoNotAge® Routine stamp with a DNA helix markDoNotAge® Routine stampPriceless
  • DoNotAge® PerformanceDoNotAge® Performance$95.00Free
You pay$203.00
Add to your subscription

Each one arrives with every subscription delivery, and you can remove it any time.

Product information
Ingredients
7g creatine. 4g Nitralis®. 2g NAC.
Daily dose
One sachet a day, mixed with water.

A DoNotAge® Routine every 4 weeks for someone you care about. You pay, and we let them know by email.

Pause or cancel any time

Yearly$2,222.00every year$6.09 per day

Pay annually for your DoNotAge® Routine for the best price.

13 free DoNotAge® Performance pouches with your first year

Choose an annual DoNotAge® Routine subscription between November 1 and November 30 and get a full annual supply of DoNotAge® Performance free.

Also in the DoNotAge® Routine range

DoNotAge® Performance

DoNotAge® Performance is the other half of our DoNotAge® Routine range: creatine, Nitralis® and NAC in one daily sachet, for people who exercise. It is taken on top of DoNotAge® Routine.

  • Creatine7 g
  • Nitralis®4 g
  • NAC2 g

Creatine, Nitralis® and NAC in one daily drink.

Explore DoNotAge® Performance
Subscriptions ship free to the US, the UK, the EU, Canada, Australia and New ZealandMoney-back guarantee

100% money-back guarantee Take DoNotAge® Routine daily for 6 consecutive months. If your NAD+ levels haven't increased, we refund every single payment you've made. It's already proven it raises NAD+ levels in an independent human clinical trial. Read the full terms.

A daily habit you can keep.

One sachet, mixed with water. DoNotAge® Routine brings 15 foundational longevity ingredients into one simple daily drink, at the right doses. The finished product has been tested in human clinical trials.

Prefer individual supplements? Click here for all our supplements

One minute a day

  1. Tear open one sachet and pour it into the shaker we send you.
  2. Add 400 ml (about 13 oz) of water and shake for a few seconds.
  3. Take it with your first meal, at the same time each day.
  4. Stamp the day. That is the whole routine.
DoNotAge® Routine stamp with a DNA helix mark

Stamp each day and watch the habit build. Your stamp comes free with your first 4-weekly or yearly subscription.

A simpler format can make it easier to remember your daily supplement.

One sachet, one shaker and a small moment for yourself.

$7.25 a day · Subscriptions ship free to the US, the UK, the EU, Canada, Australia and New Zealand

Research on the complete formula

Read the research behind DoNotAge® Routine.

  • 76%Average increase in NAD+ levels
  • 2×Wellbeing scores doubled
  • 100%Said they would continue taking it

DoNotAge® Routine and research

Studied as a finished product.

The DoNotAge® Routine studies tested the finished product you receive. Explore the human clinical trials measuring NAD+ levels and wellbeing.

What our members say

  • Johnny & Heidi
  • Calie
  • Jodie

Quality. Purity. Evidence.

Know what you are taking, how it was tested and what the research can tell you.

  • Purity

    What is in this batch?

    Look for proof of what the ingredient is and how pure your batch is. Testing the raw ingredient and testing the finished product are two different checks.

  • Potency

    Which amount and form?

    Review every ingredient amount on the label. Compare the studied form and dose with the product, rather than relying on an ingredient name alone.

  • Proof

    What was actually studied?

    A study of one ingredient is not a study of the whole formula. Look at who was studied, for how long, and what was measured.

Details

Ingredients & doses

Ingredient names and quantities from the published DoNotAge® Routine label.

The published DoNotAge® Routine ingredient panel

  • SIRT6Activator®Activates the longevity gene1600 mg
  • Pure NMNRestores cellular energy1000 mg
  • Nitralis®Increases blood flow and performance400 mg
  • GlycineSupports sleep and recovery2000 mg
  • TMGBoosts cellular efficiency1000 mg
  • Ca-AKGSupports energy and metabolism800 mg
  • Trans-ResveratrolActivates repair pathways500 mg
  • QuercetinReduces cellular damage400 mg
  • Magnesium bisglycinatePromotes relaxation and rest250 mg
  • SulforaBoost®Cellular protection at scale230 mg
  • CoQ10Supports heart and energy200 mg
  • High molecular weight hyaluronic acidHydrates and protects cells200 mg
  • SpermidineSupports cellular repair8 mg
  • Vitamin K2 (MK-7)Bone and heart support120 µg
  • Vitamin D3Bones, muscles and inflammation125 µg
Servings
28 sachets
Serving size
1 sachet daily
How to take it
  1. Tear open one sachet and pour it into the shaker we send you.
  2. Add 400 ml (about 13 oz) of water and shake for a few seconds.
  3. Take it with your first meal, at the same time each day.
  4. Stamp the day. That is the whole routine.
Shipping, returns & payment
  • Your DoNotAge® Routine subscription ships free to the US, the UK, the EU, Canada, Australia and New Zealand. For everywhere else, checkout shows the delivery cost for your country.
  • Pause, skip, change or cancel your subscription any time in My Account.
  • NAD+ money-back guarantee: take DoNotAge® Routine daily for 6 consecutive months, and if your NAD+ levels haven't increased, we refund every payment you've made. Conditions apply.
Read delivery information
    Guarantee terms

    Compare the ingredients, line by line.

    See exactly what's in every serving.

    • Active ingredients

      15 compounds, properly dosedDoNotAge®
      10 compounds, low dosages10-compound
      3 compounds, low dosages3-compound
    • Research area: SIRT6

      SIRT6Activator® 1600 mgDoNotAge®
      No10-compound
      No3-compound
    • Designed for people above 35

      YesDoNotAge®
      No10-compound
      No3-compound
    • Research area: NAD+

      cellular energy

      NMN 1000 mgDoNotAge®
      NMN 300 mg10-compound
      No3-compound
    • Research area: nitric oxide

      blood flow & oxygen

      Nitralis® 400 mgDoNotAge®
      No10-compound
      No3-compound
    • Research area: SIRT1

      metabolic health

      Resveratrol 500 mgDoNotAge®
      Resveratrol 250 mg10-compound
      No3-compound
    • Research area: cardiovascular health

      heart

      CoQ10 200 mgDoNotAge®
      No10-compound
      No3-compound
    • Research area: autophagy

      cellular cleansing

      Spermidine 8 mgDoNotAge®
      Spermidine 3 mg10-compound
      No3-compound
    • Research area: cellular senescence

      Quercetin 400 mg + SulforaBoost® 230 mgDoNotAge®
      Quercetin 250 mg10-compound
      No3-compound
    • Research area: Nrf2

      SulforaBoost® 230 mgDoNotAge®
      No10-compound
      No3-compound
    • Research reports

      Human clinical trials of the finished productDoNotAge®
      Celebrities and marketing10-compound
      Celebrities and marketing3-compound
    • Primary focus

      Providing what worksDoNotAge®
      Celebrities and marketing10-compound
      Celebrities and marketing3-compound
    • Aging biology research

      All 12 hallmarksDoNotAge®
      Some, but dosages far too low10-compound
      1 to 2 hallmarks3-compound

    Explore your daily DoNotAge® Routine

    What are the hallmarks of aging?

    The hallmarks of aging are the 12 ways scientists group the changes that happen in our bodies as we age. Open each one to see which DoNotAge® Routine ingredients are linked to it.

    • Telomere attrition(Shortening of chromosome caps)
      • SIRT6Activator®Activates SIRT6, which helps keep telomeres stable
      • NMNRestores NAD+, which is crucial for telomeres
      • SpermidineMay help protect telomere length
    • Epigenetic alterations(Changes in gene expression)
      • SIRT6Activator®Directly influences epigenetic control
      • NMNSupports cellular maintenance & sirtuins
      • Ca-AKGSupports mitochondrial metabolism
      • GlycineSupports energy and metabolic health
      • TMGSupports methylation, a core epigenetic process
    • Deregulated nutrient sensing(Cells non-responsive to nutrients)
      • Ca-AKGSupports metabolic signaling and efficiency
      • CoQ10Essential for mitochondrial function
    • Loss of proteostasis(Protein misfolding and buildup)
      • SulforaBoost®Activates NRF2, supporting protein quality control
      • GlycineSupports protein synthesis and repair
      • MagnesiumRequired for proper protein folding
    • Cellular senescence(Build up of dysfunctional “zombie” cells)
      • QuercetinA powerful senolytic that helps clear dysfunctional cells
      • SpermidinePromotes autophagy to remove damaged cells
      • SIRT6Activator®Reduces the SASP inflammatory response from senescent cells
    • Mitochondrial dysfunction(Energy production declines)
      • NMNRestores NAD+ to fuel mitochondrial energy production
      • CoQ10Directly supports the electron transport chain
      • Ca-AKGSupports mitochondrial metabolism and energy
    • Altered intercellular communication(Cells stop talking well)
      • Nitralis®Boosts nitric oxide to improve vascular signaling
      • SIRT6Activator®Reduces inflammatory cytokines that disrupt cell signaling
      • ResveratrolSupports healthy inflammatory signaling
    • Stem cell exhaustion(Reduced ability to regenerate)
      • NMNRestores NAD+ to support stem cell activity
      • SpermidinePromotes autophagy to maintain stem cell health
      • Ca-AKGSupports the metabolic environment needed for regeneration
    • Chronic inflammation(Persistent low-grade inflammation)
      • SIRT6Activator®The most powerful anti-inflammatory
      • SulforaBoost®NRF2 activation reduces inflammation
      • QuercetinAnti-inflammatory and antioxidant
    • Disabled macroautophagy(Reduced cellular cleanup)
      • SpermidineThe most direct activator of autophagy
      • SulforaBoost®Activates NRF2 to support cellular cleanup pathways
      • QuercetinSupports autophagy induction
    • Genomic instability(DNA damage accumulation)
      • SIRT6Activator®Directly activates SIRT6, a key DNA repair and genome-stabilizing protein
      • NMNSupports DNA repair by restoring NAD+ levels
      • ResveratrolSupports cellular repair pathways
    • Dysbiosis(Gut microbiome imbalance)
      • SpermidineSupports gut cell renewal via autophagy
      • GlycineSupports gut lining integrity
      • SulforaBoost®Reduces gut inflammation via NRF2
    López-Otín et al. · Cell (2023) · Hallmarks of aging
    The DoNotAge® shaker, storage box, stamp, sachet and 28-sachet pouch

    A community that helps research move forward.

    DoNotAge.org brings ingredients, researchers and people interested in healthy aging together. Quality and purity matter in a laboratory and in a daily routine.

    • Is this the expensive way to do things? Yes.
    • Is it the slow way to do things? Yes.
    • But it is the right way, and the only effective way.

    We support research with funding, ingredients for studies and collaborations. DoNotAge® Conference shows examples, from ongoing human studies to early discoveries.

    Meet the organization

    Uncompromising quality.

    Researchers choose DoNotAge.org ingredients for their purity and quality, using them in research and human clinical trials.

    The same commitment to quality goes into your daily DoNotAge® Routine.

    Warning signs in a supplement brand

    • Heavy use of celebrities or influencers
    • Claims like “research-led” or “science-backed” with no published trials
    • No real company address or research facility
    • No clinical trials using the actual product being sold

    Explore DoNotAge® Conference in London to meet the researchers and understand the projects our community helps support.

    One sachet. One daily habit.

    How to enjoy it

    Mix one sachet with 400 ml of water in your shaker and take it with your first meal each day.

    Taste

    Add water to suit your taste.

    Explore your daily DoNotAge® Routine

    Who is this for?

      • For people who want long-term health, not quick fixes
      • For people 35 and older
      • Not for people who want instant stimulants
      • Not for people who won't take it daily
    A sachet being poured into the DoNotAge® shaker outdoors

    Build your DoNotAge® Routine, one day at a time.

    A daily habit starts with a choice that fits your needs and budget.

    1. 30days

      Get to know your ingredients and settle into your daily moment.

      Make room for a daily habit.

    2. 60days

      Notice how you feel and note any questions: our support team is happy to talk them through. Everyone's experience is their own.

      Tune in to how you feel.

    3. 90days

      Hear first-hand experiences on member calls, and explore the measured study outcomes on our research page. Everyone responds in their own way.

      Let the evidence guide you.

    A green sea turtle resting on a coral reef in blue water

    The shaker

    Better for your body. Better for the planet.

    A stainless steel reusable shaker for your daily DoNotAge® Routine.

    Not as a gimmick. As a replacement.

    That shaker directly funds the removal of plastic from the ocean in communities where waste has no recycling system.

    • Each shaker removes the equivalent of 1 kg of plastic from the ocean
    • Supports fair, dignified work
    • Designed to last years, not months

    Longevity isn’t just about your body. It’s about the systems you support.

    If you’re committing to long-term health, it makes sense to reduce long-term waste too.

    Frequently Asked Questions

    Questions about the subscription, label and research.

    Why is it subscription only?

    DoNotAge® Routine is designed to be part of your daily life. Consistent use over a long period helps the benefits build over time. A subscription helps you keep that daily habit.

    How do I cancel?

    Manage or cancel your subscription any time in My Account. You can also pause or skip a 4-weekly plan. If you change your mind, restart from My Account. Your subscription terms set out the details.

    Contact subscription support
    How much is shipping?

    Your DoNotAge® Routine subscription ships free to the US, the UK, the EU, Canada, Australia and New Zealand. Every delivery is tracked, and we aim to dispatch within 48 hours. For other destinations, checkout shows the delivery cost for your country before you pay.

    Read delivery information
    What is in DoNotAge® Routine?
    • SIRT6Activator®1600 mg
    • Pure NMN1000 mg
    • Nitralis®400 mg
    • Glycine2000 mg
    • TMG1000 mg
    • Ca-AKG800 mg
    • Trans-Resveratrol500 mg
    • Quercetin400 mg
    • Magnesium bisglycinate250 mg
    • SulforaBoost®230 mg
    • CoQ10200 mg
    • High molecular weight hyaluronic acid200 mg
    • Spermidine8 mg
    • Vitamin K2 (MK-7)120 µg
    • Vitamin D3125 µg
    When and how should I take DoNotAge® Routine?

    Mix one sachet with 400 ml of water in your shaker and take it with your first meal each day.

    How do I know it is working?

    Notice how you feel as you build your daily habit: your energy, sleep and overall wellbeing are useful things to keep track of. Changes can be gradual, and benefits build over months of consistent use. For a measurable check, test your NAD+ levels before you start and again after 6 consecutive months of daily DoNotAge® Routine. If your NAD+ levels haven't increased, our money-back guarantee refunds every payment you've made, subject to the full conditions.

    Read all guarantee conditions
    Is DoNotAge® Routine suitable for daily use?

    Yes. DoNotAge® Routine is designed for daily use. The formula is built to support long-term cellular health, so taking it consistently is the best way to experience its benefits. Each sachet contains carefully selected ingredients in amounts intended for regular, ongoing use.

    How can I take a break from my subscription?

    Pause or skip a 4-weekly plan in My Account, or review your cancellation options and subscription terms. Manage your renewals in My Account when you change your daily plan.

    How can I save with member referrals?

    Share your referral link with friends to reduce the renewal price of your eligible 4-weekly DoNotAge® Routine. My Account shows your link, qualifying friends and current saving.

    Start with the plan that suits your budget, then share your link to bring your price down.

    Join the DoNotAge.org family

    Follow the research as it develops.

    Get research updates, conference highlights and clear explanations of the ingredients we study and supply.

    By signing up you agree to get DoNotAge.org news and offers by email. Unsubscribe at any time. Privacy policy

    Your questions, answered.

    Find help with DoNotAge® Routine, individual supplements, research and your account. Our team is here when you need a more personal answer.

    Find answers to common questions

    Contact Member Support

    Send us a message. We’re here to help.

    hello@donotage.org
    View all research partners
    • The Alliance for Longevity Initiatives
    • ARDD
    • Aarhus University Hospital Denmark
    • BSRA
    • Bloodo
    • Citrus Labs
    • Imperial College London
    • King’s College London
    • Newcastle University
    • Queen Mary University of London
    • University of Rochester Medicine
    • Teesside University
    • TriHealth
    • TruDiagnostic
    • UNICAMP
    • University of Exeter
    • University of Nottingham
    • University of Birmingham
    • University of Edinburgh
    • University of Glasgow
    • University of Lincoln
    • University of Oxford
    • University of Southampton
    • University of Arizona
    • University of Central Lancashire
    • University of Hertfordshire
    • University of Oslo
    • University of Rochester
    • Washington University in Saint Louis USA
    • Yong Loo Lin School of Medicine
    • LifeLab1
    • University of Southern California
    • University of Auckland
    • Ulster University
    • Evandro Fang Lab
    • The Clock Foundation
    • Rejuvenation Science Institute
    • NO-Age Network
    • National University of Singapore
    • University of Minnesota
    • Texas Tech University

    Start with one sachet a day.

    $203.00 every 4 weeks · $7.25 a day · DoNotAge® Routine subscription terms apply

    $203.00Every 4 weeks · Subscription terms apply