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Made to GMP & ISO9001 standards
Third-party tested, batch by batch

Ca-AKG Supplement

Supports your cellular metabolism, energy production and healthy aging pathways.

Boosts Cellular Energy
Enhances Cognitive Function
Improves Physical Resilience
Optimizes Metabolism
Promotes Bone Health

Each capsule contains 400mg calcium alpha ketoglutarate (Ca-AKG).
Recommended daily serving: 800mg.

$49.00

In stock

Purchase options

One-time purchase

Total$49.00

Ca-AKG Supplement

$49.00

Made to GMP & ISO9001 standards
Third-party tested, batch by batch

A closer look at Ca-AKG Supplement

Ca-AKG Supplement is part of our established individual supplement range. Review the ingredients, available format and applicable label alongside your own preferences.

Explore the linked studies alongside the product information. Keep each finding within the ingredient form, study model and conditions actually tested.

DoNotAge^® Routine and DoNotAge^® Performance provide daily sachet formats within our One-A-Day range. Individual supplements remain available for people who prefer to choose ingredients separately.

Quality, purity and clear information matter across the range. Our team can help you find the relevant product and batch information.

How It Works: The Role of Ca-AKG in Metabolic Health & Cellular Function

Healthy aging is not just about the passage of time, it’s about how well your cells maintain their function as you grow older. At the core of this process is your body’s ability to produce energy, repair itself, and manage the natural stress of metabolism.

Calcium Alpha-Ketoglutarate (Ca-AKG) is a key molecule involved in the Krebs Cycle: the critical process your cells use to generate energy. Beyond fueling metabolism, Ca-AKG plays a role in supporting bone and muscle health, aiding cellular detoxification, and helping the body manage inflammation.

Why Ca-AKG Matters:

As we age, natural levels of alpha-ketoglutarate decline, which may impact how efficiently our cells produce energy and repair damage. This decline is linked to physical frailty, reduced muscle mass, and metabolic slowdown; factors that contribute to age-related decline in health.

By restoring this critical compound, Ca-AKG helps maintain core metabolic functions essential for healthspan supporting your body’s resilience, strength, and vitality.

What the Research Shows:

Central to Energy Production Ca-AKG fuels the Krebs Cycle, driving the process that generates ATP, the energy your cells need to function optimally.
Supports Bone & Muscle Strength Essential for collagen synthesis, Ca-AKG helps maintain bone density and muscle integrity, key factors in staying strong and mobile with age.
Promotes Cellular Cleansing and Detoxification Ca-AKG plays a role in removing excess nitrogen and metabolic waste, supporting healthy cellular environments.
Helps Moderate Inflammatory Responses Research suggests Ca-AKG may help reduce markers of systemic inflammation, supporting healthier aging at the cellular level.

At DoNotAge.org, we don’t follow industry trends. We lead scientific discovery. Our Ca-AKG is trusted and used by researchers in clinical settings exploring how this molecule supports better health outcomes and preserves metabolic function over time. It’s also publicly backed by Dr. Nick Engerer, a longevity expert, researcher, and member of the DoNotAge.org advisory board. He considers Ca-AKG a foundational part of his personal healthspan protocol.

BENEFITS OF PURE Ca-AKG

✔ Supports Energy Metabolism: Fuels cellular processes essential for sustained energy production

✔ Promotes Bone and Muscle Health: Contributes to skeletal strength and muscle maintenance as you age

✔ Optimizes Metabolic Function: Plays a critical role in amino acid metabolism and nutrient utilization

✔ Encourages Healthy Cellular Function: Helps protect cells from metabolic stress and supports detoxification pathways

✔ Supports DNA and Cellular Maintenance: Aids natural repair mechanisms essential for healthy aging

✔ Helps Moderate Inflammatory Response: Supports the body’s ability to manage oxidative stress and maintain resilience

PRODUCT DETAILS

✔ Pure Calcium Alpha-Ketoglutarate (Ca-AKG): Selected for its essential role in metabolic and cellular health

✔ No Fillers. No Additives. No Compromises: Just the ingredient used by researchers in clinical studies

✔ Formulated for Bioavailability: Easily mixed into water or your preferred beverage for effective absorption

✔ Vegan, Non-GMO, and Allergen-Free: Free from synthetic ingredients, preservatives, or animal derivatives

✔ Third-Party Lab Verified: Every batch tested to meet the highest standards for purity and safety

At DoNotAge.org we prioritize health over hype, delivering ingredients used in global research, not just marketed as supplements.

Alan Graves

Founder & Clinical Research Advisor

DoNotAge.org

The Science Behind Ca-AKG

The aging process impacts your body from the inside out, not just in how you feel, but in how your cells function. As the years pass, the body produces less of key molecules that are essential for energy, recovery, strength, and resilience.

Calcium Alpha-Ketoglutarate (Ca-AKG) is one of those molecules. It plays a vital role in your body’s energy cycle, detoxification process, and tissue maintenance. But as levels decline with age, so does the efficiency of your metabolism, muscle integrity, and ability to clear waste at the cellular level.

That’s why researchers are turning to Ca-AKG and why it’s being studied as one of the most promising ingredients in the field of healthy aging and healthspan science.

Developed by a Health Research Organization, Not a Supplement Company

At DoNotAge.org, we don’t market hype. We fund and lead real scientific research.

As a Health Research Organization, we develop and supply research-leading ingredients that are actively used in clinical trials and scientific investigations. Ca-AKG is one of our core ingredients chosen by scientists because it meets the gold standard of purity, consistency, and performance.

Every batch is tested in-house and verified by third parties. There are no fillers. No shortcuts. Just the clinically relevant form of Ca-AKG, delivered with precision for optimal impact.

What the Science Says

Unlike many molecules associated with aging, Ca-AKG supports multiple systems in the body at once. Its role in the Krebs cycle helps cells generate energy efficiently. It also supports the body’s natural detox pathways and contributes to muscle and bone maintenance, key to staying active and resilient with age.

Recent preclinical studies have shown promising results in models of biological aging, physical decline, and systemic inflammation.

✔ Fuels Energy Metabolism: Powers ATP production inside your cells*

✔ Helps Maintain Muscle & Bone Health: Supports strength and physical performance over time*

✔ Reduces Inflammation: Supports a healthy immune response and reduces cellular stress*

✔ Aids in Detoxification: Helps the body process and eliminate metabolic waste*

✔ Supports DNA and Cellular Integrity: Contributes to repair systems linked to long-term resilience*

A Scientific Breakthrough in Longevity

Our Ca-AKG is used by researchers not because of branding, but because of its performance. It is one of the few forms available globally that meets the criteria required for clinical application. That’s why leading health scientists, including Dr. Nick Engerer, choose to include Ca-AKG in their own protocols.

We don’t copy the industry. We build what comes next.

Ca-AKG is part of our mission to help people stay strong, active, and biologically younger for longer, using proven tools grounded in modern science.

Scientific References & Studies:

If you’re focused on protecting your energy, recovery, and resilience as you age, Pure Ca-AKG is one of the smartest ways to support your body from the inside out.

Experience research in action. Try Pure Ca-AKG today.

Alan Graves

Founder & Clinical Research Advisor

DoNotAge.org

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Ingredient illustration published with ca akg

Calcium Alpha-Ketoglutarate (Ca-AKG): Core Support for Energy, Recovery, and Cellular Health

At DoNotAge.org, we don’t follow industry trends, we lead global health research. Our Ca-AKG is used by scientists in clinical trials because it meets the purity, consistency, and performance standards required for serious scientific application.

Ca-AKG is a molecule your body naturally produces. It plays a central role in energy metabolism, supports detoxification, and helps maintain structural integrity in muscles and bones. But levels drop significantly with age, which can contribute to fatigue, physical decline, and impaired cellular repair.

Clinical research has shown that restoring AKG levels may support:

✔ Cellular Energy: Fuels the Krebs cycle to power your cells and support metabolic vitality* ✔ Muscle & Bone Health: Helps maintain strength and resilience through collagen and protein synthesis* ✔ Inflammation Management: Supports a healthier immune response and lowers cellular stress markers* ✔ Detoxification: Aids in clearing ammonia and metabolic byproducts to protect cellular function* ✔ Healthy Aging: Contributes to DNA stability and long-term cellular maintenance*

At DoNotAge.org, our Ca-AKG is not a generic supplement. It’s a research-leading ingredient actively used by experts investigating how to extend healthspan and improve age-related outcomes. Every batch is tested in-house and independently verified, with no unnecessary fillers or additives.

This is real science not marketing. Just clinically relevant Ca-AKG, delivered with the integrity you expect from a Health Research Organization.

Pure Ca-AKG Capsules: Clean, Clinically Tested Form

Each capsule delivers pure calcium alpha-ketoglutarate, formulated with precision and care. Used by health researchers and trusted in clinical settings, our Ca-AKG is encapsulated without fillers or unnecessary additives, just the ingredient your body needs, delivered in a clean and convenient format.

✔ Non-GMO and Allergen-Free: Free from preservatives, synthetic fillers, and common allergens* ✔ Easy-to-Take Capsules: Precisely dosed for consistency and convenience* ✔ Vegan and Clean: Plant-based capsules made without gelatin or animal byproducts* ✔ Gentle on Digestion: Designed for everyday use, even for those with sensitivities* ✔ Independently Tested: Verified for purity, identity, and consistency in every batch*

At DoNotAge.org, we provide Ca-AKG that meets the standards required by leading health researchers with full transparency, no shortcuts, and no compromises.

The DoNotAge.org Quality Guarantee

This product comes with the DoNotAge.org Quality Guarantee. We proudly guarantee purity and quality from our facility to your home, no matter where you live.

✔ Produced to GMP and ISO9001 Standards: Ensuring the highest levels of manufacturing excellence.* ✔ Science-Led & Rigorously Tested: Formulated for superior effectiveness and safety.* ✔ Full Instructions Included: Your order comes with easy-to-follow guidelines for optimal results.* ✔ 100% Vegan & Clean: Free from unnecessary additives, making it suitable for all dietary preferences.*

At DoNotAge.org, we are committed to delivering science-leading solutions that empower people to live longer, healthier lives. Ca-AKG is part of our greater mission to advance longevity research and make cutting-edge breakthroughs accessible to all.

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

World Leading Ingredients, Built on Precision and Purity

At DoNotAge.org, we are a Health Research Organization. We don’t follow the supplement industry, we help shape the future of health through science. Our mission is to investigate, refine, and deliver ingredients that are actively used by researchers in clinical trials, with every batch tested for identity, purity, and performance.

✔ Manufactured in GMP and ISO9001 Certified Facilities: Meeting the highest global standards for safety and consistency

✔ Independently Tested: Verified for purity, identity, and composition without relying on supplier claims

✔ Used in Clinical Research: Ca-AKG is studied for its role in metabolism, inflammation, energy production, and physical function

✔ No Fillers or Additives: Only what your body needs, with nothing unnecessary

✔ Transparent from Source to Capsule: What’s on the label is what’s in the bottle, every time

At DoNotAge.org, we don’t make vague promises. We deliver ingredients trusted by scientists and used in real-world research with no shortcuts and no compromises.

DoNotAge.org Quality Guarantee

This product comes with the DoNotAge.org Quality Guarantee, ensuring uncompromised purity and potency from our facility to your doorstep, no matter where you live.

✔ GMP & ISO9001 Certified: Manufactured under the highest standards. ✔ Third-Party Lab Tested: Verified for purity, potency, and safety. ✔ Bioavailable & Effective: Every ingredient is carefully curated for maximum absorption and longevity benefits. ✔ Vegan & Allergen-Free: No fillers, additives, or unnecessary ingredients.

Full instructions for use are included with every order.

Join us in our mission to revolutionize health and longevity, because living longer is only worth it when you're living better.

Committed to Extending Healthy Lifespan

At DoNotAge.org, our mission is simple: To extend healthy lifespan for as many people as possible.

We believe that longevity should be accessible to everyone, not just the elite. That’s why we provide the world’s purest, research-leading supplements at the lowest possible cost so more people can benefit from the latest breakthroughs in health and aging. There's a reason our longevity ingredients are actually used in world-leading studies, and by world renown longevity experts.

We work hand-in-hand with leading scientists, longevity researchers, and medical professionals to ensure that every product we offer is at the cutting edge of human health and performance. Our advisory board includes decorated longevity scientists and medical experts, ensuring that our formulations are backed by the latest research and clinical evidence.

We aren’t a supplement company, we are a global movement of over 200,000 individuals dedicated to extending and improving human health. With a growing community spanning the United States, Canada, Australia, Germany, and beyond, we are united in a shared mission: helping people live longer, healthier, and more vibrant lives.

Why We Do What We Do

Most supplement brands focus on profit. We focus on science. We are not here to maximize profits. We are here to maximize your health and longevity.

✔ Our Commitment to Research: We actively collaborate with scientists, researchers, and anti-aging experts to stay ahead of the latest breakthroughs. ✔ Making Longevity Accessible: We keep our prices as low as possible so that more people can benefit from life-extending science. ✔ No Compromises on Quality: Every batch of Ca-AKG meets the strictest testing and safety standards in the industry.

At DoNotAge.org, we are a Health Research Organization, our profits fund longevity studies and conduct our own research, ensuring that our ingredients are actually used in clinical trials.

Product & Usage

What is Ca-AKG, and how does it work?

Ca-AKG stands for Calcium Alpha-Ketoglutarate, a compound naturally produced in the body. It plays a critical role in the Krebs cycle, which is how your cells generate energy. As you age, levels of AKG decline and that decline has been associated with reduced energy, increased inflammation, and loss of muscle and bone strength. Supplementing with Ca-AKG helps restore balance to these systems and supports healthy aging at the cellular level.

How should I take Ca-AKG?

Simply take the capsules with water. Each capsule contains 400mg of Ca-AKG. Most people take 2 capsules per day, but you can adjust based on your goals or consult your healthcare provider.

What is the recommended daily dosage?

The recommended daily dosage for Ca-AKG is 400mg to 800mg, taken as 1 to 2 capsules with water.

When is the best time to take Ca-AKG?

Ca-AKG can be taken at any time of day, but many people prefer taking it in the morning to support daytime energy and physical performance.

Is Ca-AKG safe to take every day?

Follow the product label and ask a qualified healthcare professional whether daily use is appropriate for you, especially if you have a medical condition or take medication.

What age should I start taking Ca-AKG?

Ask a qualified healthcare professional whether this product is appropriate for your age and health needs.

Quality & Purity

Is Pure Ca-AKG suitable for vegans?

This product is suitable for vegans and vegetarians.

Are there any fillers in your Ca-AKG capsules?

The capsules contain only calcium alpha-ketoglutarate in a plant-based cellulose shell.

Is it tested for purity?

Every batch is tested for identity, purity, and consistency.

How should I store Ca-AKG?

Store in a cool, dry place away from heat and direct sunlight.

Delivery

How fast do you ship once I place my order?

Orders are usually dispatched within 48 hours. See the delivery options and cost for your country at checkout before you pay.

Additional Questions

Can Ca-AKG be taken with medication?

Ca-AKG is generally well tolerated and can be taken alongside other supplements. However, if you are taking prescription medication or have an existing medical condition, we recommend speaking with your healthcare provider before starting.

Is Ca-AKG safe during pregnancy or while nursing?

There is limited research on Ca-AKG during pregnancy or breastfeeding. If you are pregnant, nursing, or planning to become pregnant, please consult your doctor before use.

Can children take Ca-AKG?

Ca-AKG is formulated for adult use. If you are considering it for someone under the age of 18, please consult with a qualified pediatrician or healthcare professional.

Where can I learn more about Ca-AKG and the science behind it?

You can explore our Science & Research page for more information on the studies behind Ca-AKG and other ingredients we provide. For additional support, our team is happy to assist, reach out to us at hello@donotage.org.

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