DoNotAge.org exists to further longevity science. A large part of that is providing researchers with ingredients they can trust to run clinical trials.

As the only verified activator of Sirtuin 6 in the world, SIRT6Activator® is the ingredient we get asked for the most. We were glad to provide it for a recent trial, which has now finished.

The study

Researchers wanted to find out whether they could improve the health markers of older people using multiple ingredients and treatments together, rather than one in isolation.

Twenty participants took part in a series of tests to establish their baseline health. The tests covered several markers of ageing, including muscle strength and mass, immune function, and brain performance.

All participants were then given interventions the researchers considered foundational to healthy ageing: sleep and diet recommendations, protein, and SIRT6Activator®. After eight weeks, they were tested again against the same markers.

What happens next

The study finished in February and the researchers are still compiling the data. When the results are available, they could give us valuable information about the right approach to healthy ageing.

That SIRT6Activator® was treated as a foundational part of the protocol won't surprise anyone in our community who has used it. As always, you'll be the first to know when the results land.

Trial reference: link.springer.com/article/10.1007/s11357-026-02394-6