Pure Apigenin
Pure Apigenin is often used to regulate CD38 levels, and help boost NAD+ levels in the body.
Boosts NAD
Anti-Ageing
Inhibits CD38
Anti-anxiety
Neuroprotector
Third Party Tested
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Description
Apigenin is a naturally occurring flavonoid, that inhibits CD38, and in turn, boosts NAD+ levels.
Studies have shown that apigenin alone can double your NAD+ levels in the body, without the supplementation of NAD+ boosters! When apigenin assists with increasing NAD+ levels, it can protect against obesity and fatty liver. We also see an increase in sirtuin activation with the use of apigenin. Finally, apigenin has also been shown to support a healthy heart.
Many apigenin products on the market do not store well and lose potency very quickly. DoNotAge.org’s Pure Apigenin, bound to beta glycosides, is extracted from nature and fully stabilised to keep potency over the long term.
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Key Benefits
Apigenin has been studied for its potential health-promoting effects, including antioxidant, anti-inflammatory, and neuroprotective properties. It is believed to exert these effects through various mechanisms, such as scavenging free radicals and modulating inflammatory pathways.
Anti-Inflammatory Effects: Apigenin has been shown to inhibit the production of inflammatory molecules and cytokines, which play a role in the inflammatory response. By reducing inflammation, apigenin may help alleviate symptoms of inflammatory conditions like arthritis and inflammatory bowel disease.
Neuroprotective Effects: Some studies have indicated that apigenin may have neuroprotective effects, potentially reducing the risk of neurodegenerative diseases like Alzheimer's and Parkinson's disease. It may help protect neurons from damage and improve cognitive function.
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Ingredients
- 250mg of pure apigenin
- Vegetable cellulose capsule
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How it Works
Apigenin is the most potent known inhibitor of CD38, and when administered, NAD levels increase. It reduces CD38 by around two-thirds, which leads to a doubling in NAD levels.
Apigenin can reduce anxiety without negative effects, as well as protect the brain from decline. Apigenin is anti-inflammatory as well as anti-diabetic. Other benefits include:
- Works as an antioxidant.
- Has antimicrobial effects
- Reduces pain.
- Supports heart health
- Boosts brain function
- Reduces anxiety
- Reduces depression
- Works as an anticancer agent.
- Can increase testosterone levels.
Many apigenin products available on the market don’t store well and quickly lose their efficacy. Pure Apigenin from Do Not Age is derived from nature and thoroughly stabilised to maintain potency over time. It is coupled to beta glycosides.
Useful links:
- Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome
- Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects
- Quercetin, kaempferol and biapigenin from Hypericum perforatum are neuroprotective against excitotoxic insults
- Risks and Benefits of Commonly used Herbal Medicines in México – PMC
- Antihyperglycemic effect of Cephalotaxus sinensis leaves and GLUT-4 translocation facilitating activity of its flavonoid constituents
- Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages
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Subscribe & Save Explained
We have four options. 250mg/day, 500mg/day, 750mg/day and 1g/day.
- Members who choose 250mg/day will receive 1 x 366 capsule containers to allow them to have 1 capsule each day for 12 months.
- Members who choose 500mg/day will receive 2 x 366 capsule containers to allow them to have 2 capsules each day for 12 months.
- Members who choose 750mg/day will receive 3 x 366 capsule containers to allow them to have 3 capsules each day for 12 months.
- Members who choose 1g/day will receive 4 x 366 capsule containers to allow them to have 4 capsules each day for 12 months.
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Frequently Asked Questions
How to take?
We recommend to take our Pure Apigenin with a source of fat, any time of the day.
Where do you source your Apigenin from?
Our Pure Apigenin is sourced from grapefruit. Grapefruit is extracted to get Naringin, and then becomes Apigenin through the synthetic process.
What should I take with Apigenin?
We recommend to take Pure NMN, Vitamin D3, K2 & Magnesium and SIRT6 Activator with our Pure Apigenin.
How should I store my Pure Apigenin?
We recommend to store in a cool, dry place, away from direct sunlight.
Are there any fillers in your Pure Apigenin capsules?
No. Inside the cellulose vegetable capsule is just Pure Apigenin powder.
How do you ensure the purity of your Pure Apigenin?
We test every batch of Pure Apigenin and only supply it to our members if the purity comes back as above 99%. Purity certificates can be provided on request.
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Lab Data & Awards
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Delivery Information
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Reviews
I like the dosage being high, as it fits in with Dr David Sinclair's protocol. Pure products are always betterI was taking these for a while, then I got a cold sore. I saw online that these can bring on cold sores.Apigenin has been a welcomed addition to my wellness routine. Its natural properties have provided me with a sense of calm and relaxation, making it easier to unwind after a long day.Well, all I can say is thank you. I have struggled with sleep my entire adult life and these have been a game changer.I've been incorporating these Apigenin capsules into my daily supplement routine for a while now, and I've got to say, I'm impressed with the results.My partner finds this very helpful to help him fall asleep. This is one of the supplements recommended by Andrew Huberman. I found this to help me sleep and will continue to purchase and take this in conjunction with other supplements.I was shocked at just how potent this was. It helped me to fall asleep and to stay asleep, longer than expected even. I was so impressed that when my son was having trouble sleeping I let him try one. They helped him as well, but not nearly as much as I. I am 86 years old so I'm sure my metabolism has slowed with age and thus the likely reason it worked better for me than for him, but it was definitely effective!It has a relaxing and focusing effect. I like to take it with magnesium before bed and thanks to it I have beautiful dreams.I've been taking supplements for a short time, so I won't comment on the effects - you'll probably have to wait for them. The supplement has small, easy-to-swallow capsules. The capsules are in a small and practical container with a cap. Good quality ingredients at a rather high price.I am very pleased with the benefits of this supplement. I managed to stabilize my emotional state and I sleep much better.Stress accompanies me all the time and a flood of thoughts. This supplement helps me relax and unwindBit expensive, but high qualityExcellent. I take these for when I feel that I will fall asleep with difficulty. Usual great quality from Donotage. Tablet size is easy to swallow.It works well to calm the mind and has a great relaxing effect. So give it a try if want to sleep soundly.Work seems more efficient and it is easier to relax after a long day. This is a very good quality composition that allows me to fall asleep easier and helps me relax after a long day of stress. It brings benefits.The benefit from supplementation is noticeable, but only after long-term use. For me, it manifests itself in better well-being and greater motivation to act. Simple composition, small size, convenient box.Recommended by Dr. Huberman. This is an essential part of my night time routine. I have increased and consistently maintained deep sleep over the past three months (tracking with an Oura ring). Even if I get to bed later, or my sleep is disrupted, I find that my deep sleep is higher.Rest and the ability to relax after a long day is very important, but not always possible. For a year I couldn't relax after work and I found a good quality supplement that allowed me to relax for a while. This is my second package and I am very pleased with the quality of this supplement. I recommend for benefit.Deeper Sleep
More Relaxed
CalmerRestores testosterone synthesis! Yes please.An absolute powerhouse of a supplement.
I sleep like a dead person! Crazy!Too early to tell yet.I started off with half a capsule every other day. So my body could adjust. Not taking 1-2 capsules per day, depending on how I am feeling.
No bad side effects. No taste to capsule. Capsule not too big.
Improved sleep. I feel more relaxed and calmer.This supplement is great for relaxation and anxiety levels. Can strongly recommend.I take 1-2 30 mins before I go to sleep and my deep sleep and REM sleep have both increased a great productFeel like my energy level and overall wellness have increased. Good product
slept through the night every night since started taking these.
Didn't really work for me. Felt no difference.Works perfectly, defo recommend
Great product, professionally packaged. A go to source for Apigenen - the real deal.
Feel generally better since taking. Early days so will see how it progresses.was advised to try these to help with disturbed sleep pattern. found very effective quite quickly.
Tried after listening to Huberman podcast. My sleep has been consistent and good so it seems to be helping.First time using this product. It helped with relaxation and sleep. I seem to have more energy and feel more mentally alert. Definitely need to reduce price though please.Great quality product. Has helped me to induce sleep faster and feel more rested in the mornings, improving the overall quality of my sleep.I take Apigenin every night before bed, it’s become a staple in my sleep routine and swear by it. Would recommend combining Apigenin with an Epsom salt bath.greatThis seems like a good quality product and is now part of my current supplement combination for improving cellular function. This item arrived super quick too :) Will buy againOn my second bottle and it seems to work. I have been sleeping better and feel more relaxed in the evening. Will continue to use it.Bought these as Apigenin is part of the Kaufmann Protocol for longevity.
Research indicates many benefits of supplementing Apigenin from maintaining NAD levels, to reducing inflamation.
Being a sleep aid is an added benefitDid what it said in the tin
Very good quality - 3rd party tested, excellent value, easy to swallowTaking this to inhibit CD38 and hence boost my NAD levels. Early days but I have to say I feel a lot more energy after only a week.
Also, an additional benefit, I feel a lot more relaxed and have been getting a better sleep.
Altogether this is an important supplement to takeI am on my second bottle with the aim to support healthy ageing. I choose this product because it is third-party laboratory tested for purity. The delivery is always very speedy.In my desire to have a healthy sleep regimen I turned to Apigenin as described in the Huberman Lab podcast series. It's been 3 weeks since I supplement with Apigenin and I am happy to see that I fall asleep with less effort and maintain deep sleep throughout the night. This has boosted my life satisfaction hugely.Helps me sleep great with magnesium
If you don't get your sleep routine down, everything else suffers. This completes my rather large sleep stack which I alter and adjust according to my varying needs and time of year. If you're starting out on the good sleep habit, read read and read as much as you can BEFORE you commit. It'll save you a lot of grief and possible harm but, if you get your sleep routine down as well as you can, life can rapidly become less stressful and so much more productive.
Good luck and be well! ????????????????????????????????????????????????????????The instructions says to take 2 tablets but I take one and within 20 minutes I'm in bed drifting off. I get a great sleep and wake up feeling really refreshed.
Really great product I highly recommend.These tablets are very effective.I'm one of those people who has always been a light sleeper.
These capsules are the only ones that sort of work, I've tried montmorency cherry, melatonin, valerian, hops, some sleep-aid mixtures that are natural and they have all been meh!
These capsules...so I still wake up HOWEVER I manage to fall back asleep far quicker than anything else I have tried-something unheard of before!
Even the thoughts running through my head sometimes just don't occur now.
So, it may not help 100%, but to me falling back asleep much more quicker is a big step forward!Sleep like a corpse
Sleep is hugely important to me. I have tried various protocols including magnesium but this has had the most noticeable effect in helping me get to sleep and more importantly stay asleep. I’ve also noticed increased energy levels likely due to the improved sleep. Need more time to see the other benefits, but would recommend based on the improvement in my sleep alone.
Please reduce the price!Product is a great sleep aid that’s helped me greatly getting to and staying to sleep. My wife is also now using it most nights and swears by it
I came look for the item as it’s part of Andrew Huberman’s sleep cocktailI use this for the Hubermann cocktail!
Highly recommend
There are no nasty smells or tastes and the tablets are easy to swallow. I trust that they contain what they claim to, and as such I am very pleased.I really appreciate the fact that this is a clearly marked vegan supplement with a vegetarian capsule shell. The capsules are typical size and easy enough to swallow.Incredible longevity supplement from a reliable company.
Apigenin is incredible stuff: it’s naturally found in many plants, but is especially high in camomile so if you drink camomile tea for its sleep benefits, for example, Apigenin could be beneficial there.
It is also thought to reduce depression and anxiety and, in addition, it aids and supports the NAD in your body - and that’s the magic right there.
Highly recommended.The Apigenin capsules have played a crucial role in the improvement of my sleep and relaxation. I noticed a distinct enhancement in my mood, alongside a palpable energy boost during the day.I have quite a hectic day most days and often find it difficult to unwind and sleep. The ingredients in these capsules are a really good combination. What I like about these is they work on both brain and gut level, both of which is important as the gut can cause stress and lost sleep too. Apigenin from grapefruit helps boost sleep plus it is a natural anti inflammatory as well as having other benefits. Take one an hour before bed and you will sleep better and not feel groggy in the morning.Whilst not a nutritionist and not qualified to advise others, I am able to say these have been beneficial to me, and I have seen positive results.
If you do your research, you will know what you need and if this supplement is it - these are good.
Well made, well presented, great packaging, great quality and value - highly recommended by us.This product is vegan-friendly and has been manufactured in the UK to GMP standards, ensuring that it is free from any harmful additives or fillers. The capsules are easy to swallow, making it convenient to include in my daily supplement regimen.
Overall, this product has several beneficial features, including its high purity level, vegan-friendly formulation, and its ability to support sleep and relaxation while boosting NAD+. It is an excellent choice for me as I am looking to improve my overall health and wellness and these capsules can be a valuable addition to my supplement routine.Firstly I would like to say I take a variety of vitamins and supplements as they have definitely helped me with my overall health and wellbeing.
I would recommend everyone tags up on the possible health benefits of NAD its supposed to have very good benefits for your overall health and wellbeing especially as you get older helping to rejuvenate and protect cells in your body...
I like the fact that it's mainly naturally derived.. Looks like a high quality product that would be Beneficial to try as part of your healthy routine.... I would emphasis don't just rely on pills to perform miracles.... You should try to eat and exercise and rest as part of your routine....
I would recommend that you try a tub and see how you get on....
You get a good supply two tablets a day ideally before bedtime....You will get a good supply of Vegan with no fillers, binders or additives supplement with Apigenin that is Naturally Derived from Grapefruit. It is recommended to take it as it might have the ability to help you regulate your blood glucose levels by increasing the amount of insulin you release. It can also help prevent some of the health complications of diabetes.
The capsules are medium in size, and easy to swallow, with no aftertaste (and no side effects afterwards (not that I noticed). You do have to take two capsules a day, which is a bit annoying, especially when you take other supplements during the day as well.
I think it is a very good quality supplement, but quite expensive.This is 60 capsules with no filler and also vegan is easy to swallow and no additives.
As to whether it worked, I had been taking these for about a month now and I could say that I experienced no adverse side effects like stomach discomfort or allergic reactions.
Sleep and anxiety improved as well as more energy due to a more restful sleep after a week of taking it. For my husband, it was 2 days later that he noticed that he may be having REM sleep because he remembered his dreams more vividly than before taking them.
Will definitely keep taking these.At my worst, I used to lay in bed and cry with tiredness; however, unable to rest. I now sleep for 5-6 hours, wake up and fall back asleep. It is a miracle for me! 10 STARS!!!!While I know that Apigenin has a plethora of beneficial effects, I chose it for sleep and relaxation. It has delivered more than I expected in that department. For someone with fragmented sleep for over 15 years, I am finally getting rest.
Thank you.I take this in evening and upon taking the apigenin noticed an improvement in deep sleep. I think if taken with chamomile tea would boost it effects and enhance sleep although more research needs to be done.One aspect that particularly stands out about this product is its natural derivation from grapefruit. As a vegan, I appreciate that it is plant-based and free from any animal-derived ingredients. The fact that it is manufactured in the UK to GMP (Good Manufacturing Practice) standards further assures me of its quality and reliability.While the effects of Apigenin can vary from person to person, I have personally experienced a sense of overall well-being after using this supplement. Although the effects are subtle, I feel confident that it is contributing to my overall health in a positive way.Giving up processed food is hard. It’s even harder when you have a candida overgrowth. Sugar cravings are actively sabotaging my health and well-being goals. I first heard about a apigeonin in a TikTok, talking about the anti-bacterial antifungal properties. It’s only been a couple of days, but I find it works well alongside acv, msm and other supplements whilst getting my life under control.
Only noticeable benefit is less brain fog. Hopefully I get the anti aging benefits and auto immune disease inflammation reduction properties with time. Will update you once empty. Haven’t experienced any side effects so far.It is early days yet though I think the Apigenin is working. I take it an hour before bed time.
I like and approve of the ingredients. I am a vegan and very careful about what I put into my body even supplement wise.
I was skeptical but seems to work, been strugling with sleep for a while.
SuperbWas recommended this on a podcast, and has totally changed the quality of both mine and my partner’s sleep. Not only is falling asleep easier, quality of sleep has drastically improvedTaken 30 mins before bedtime and an hour later I am ready to turn out the light
I like the fact that there are no nasty additives in this product. I also have a great night's sleep without feeling tired the next day.I started using this every night about 6 weeks ago, and my sleep quality has improved immensely. Went from getting sleep scores in the 60s and 70s according to my Samsung watch to consistently getting into the 80s and 90s every night. I fall asleep faster too, something I've always struggled with.This apigenin is great, it really does help me get sleepy!! And very easy to swallowhelps to sleepI was really optimistic about this after seeing it on Andrew Huberman’s list of preferred sleep supplements, It did not disappoint. Life changingNo adverse side effects experienced.I had never heard of Apigenin. Sleep was often terrible, would nod off only to wake up moments later and not be able to fall back to sleep.
Have used ZMA for years as a sleep aid combined with going to the gym with varying success when stumbled upon this during a quick Google search. Was pretty desperate to be honest to dial in my sleep as had been feeling dreadful so got this one based on the reviews. This is a game changer, I have slept so much better since taking this.
I sometimes stack it with the magnesium supplement but honestly on its own I have no problem sleeping.My sleep had improved slightlyThese supplements boosting NAD+ levels is great if you already take lower dose NMN in the morning and are generally into longevity supplements. This providing relaxation and quality sleep and well as increasing NAD+ levels can only benefit the body and health in long termThis is a beneficial supplement for both better sleep and anti-ageing, they are small capsules so easy to swallowIt's not a miracle cure but it measurably improves my sleepBest supplement for gastritis. I have suffered gastritis for decades on and off. I have tried so many medications and supplements, but nothing worked. One day someone recommended this supplement to me, so I have been taking it for over a month and all my pains are gone. I also bought it for my mom who has atrophic gastritis. She said she feels very comfortable in her stomach after taking it and that she feels happy as she now can eat what she likes which she has avoided for a long time because of her stomach pain. I’m extremely satisfied with the results.I sleep so well now. Amzing!Great for my hair and skin. I started taking it to help with anxiety and stress. Hair and skin improved massively which I was not expecting.Great for my hair health and sleep. Shipping was quick.I am quite renowned for being miserable. Apigenin has helped a bit.Amazing for sleep quality and duration. I stopped taking melatonin and now take this.I suffer terrible insomnia. This is really helping. I went from 2-3 hours sleep per night to 5-6 now. Have been taking this for 8 weeks.I take this for stress. It makes me calmer. You should try it.Always take this alongside NMN and my NAD levels are in the optimal rangeI look younger, my skin and hair continue to improve and my overall feeling of well-being is incredible and constant where I never felt like that in the past, especially not long term. Like anything else, results come from consistency and a long-term commitment and I will
Continue taking all of my current regimen of Sirt 6, Spermidine, Fisetin, Quercetin, and Apigenin, but being able to see results in just a few short months is nothing short of amazing. Thank you to the whole team you have that makes access to these supplements possible.I found DoNotAge.org and bought NMN, Resveratrol and Berberine. After a week of taking the supplements felt so energized it blew me away.
As someone who must navigate the world after my energy levels, which fluctuate day to day. Suddenly having tons of energy every even after a long day at work is simply amazing.
After such positive results on my energy levels and results in the gym, when taking these supplements, I decided to add more in. I started to take apigenin to help with reducing inflammation and improve my brain functioning even more.
Thanks to taking NMN, Resveratrol, Berberine and Apigenin my life has only improved. I can’t recommend it enough to people. Because of these supplements I have truly gained my body and mind back.I have been a personal trainer and fitness instructor for over 20 years. I’ve been taking pure NMN and apigenin to help my energy and recovery. I’ve never felt better and I’m in my forties. I hope to continue my anti-aging process with DoNotAge for many years to come.The supplement industry is generally awash with fake products, so it’s great to have DoNotAge who regularly provide third party testing certificates to prove that their products are pure. Their prices are also very competitiveThe products are outstanding as well as the customer service. Thanks for being amazing.
Warmest regards
Aman from LondonI have been using Resveratrol, NAD Booster, TMG, Quercetin and Apigenin for about a year. DoNotAge customer service has been excellent throughout. All queries have been answered promptly.
The main purpose of using supplements has been to combat the affects of ageing. It appears to be helping sugar levels and blood pressure; both caused by diabetes.
Just come back to restock as ran out.
